We are also interested in the mechanisms of cell polarization and polarized protein transport in epithelial cells. The enterocytes of C. elegans, as well as mammalian intestinal epithelial cells, have cell polarity defined as asymmetry in cell shape, protein distribution, and cell functions. These cells have an apical (luminal) surface that contains microvilli and are separated from the basolateral membranes by cell?cell junctions. The transparency of C. elegans facilitates the observation of developmental processes throughout its life cycle. Taking advantage of these unique characteristics, we are analysing the role of membrane trafficking in the establishment of cell polarization in intestinal cells

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Molecular mechanisms of cell polarization