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〒371-8512 群馬県前橋市昭和町3丁目39-15

RESEARCH

Expanded researches in mammals

In order to explore the preservation of many factors and mechanisms discovered in C. elegans researches, we identify homologs (analogous genes) of the related genes for them in mammals, and studies their functions using various cultured cells. For the genes with special interests, we also generates and analyzes the phenotypes of knockout mice.

Although mammals share basic gene functions with nematodes, mammals possess more complicated body systems. We are researching the abnormalities or phenotypes appear in each organ and tissue to know the significance of the target gene in mammals.

 

In the research on mammalian gametes, we started projects combining mainly genetically modified mice, imaging technologies, and cellular biology. Eggs and sperm are highly specialized cells with unique cellular structures and organelles, and these structures and organelles are now known to change very dynamically at fertilization. However, many unclear points remain in the relationship between these changes above with the quality of fertilized eggs (embryo), the effects of aging, diseases, and metabolic disorders.

Our present main focuses are cellular uptake of proteins, intracellular/ outer membrane dynamics, organelle dynamics and status changes during/after fertilization. We are now promoting approaches to understand the biology of the mammalian fertilization and the gamete quality by developing imaging systems for quantify these topics.


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群馬大学 生体調節研究所 
細胞構造分野

〒371-8512
群馬県前橋市昭和町3丁目39-15

TEL 027-220-8843
FAX 027-220-8844